There are convincing evidences from animal model system that thyroid hormone exhibits strong link with carcinogenesis through its profound impact on metabolism.However, the relationship between thyroxine and different metabolic markers to denote the stage of progression or regression of carcinogenesis is still not clear. The present study was therefore conducted to highlight the effect of thyroxine on some metabolic markers- glucose, cholesterol and total protein during 3-methylcholanthrene (3MC) induced carcinogenesis in male albino mice. In the animal group treated with single dose of 0.5mg 3-methylcholanthrene and daily dose of thyroxine, the fluctuation trend of serum glucose level was similar and which was decreased than the normal control group. The serum cholesterol level also revealed a declining trend from the normal control base line on exposure to thyroxine-3-methylcholanthrene combination and solitary 3- methylcholanthrene treated group. The total protein level showed a steady increase throughout the period of experiment which begin with 48.80% elevation and finally reached 118.86% increase on maintenance of an adequate thyroxine level in presence of 3-methylcholanthrene. The catabolic parameters represented by glucose and cholesterol were not drastically influenced but the anabolic parameter protein was considerably stabilized and augmented.
