Ovarian tumors are the second most common tumor affecting the female genital tract. Post chemotherapy, the ovarian tumors shows myriad of histomorphology and poses diagnostic challenges to the pathologists. The aim of this study is to analyse the histomorphological changes that are observed in various ovarian tumors following chemotherapy and to assess the prognosis based on the variables. During the one year study period, eleven cases were received. In majority of the cases the residual tumor size was more than five centimetre. Mild fibrosis, mild inflammatory reaction and grade I and II residual tumor was seen in majority of the patients. 45.5% of the tumor showed necrosis. Pre-treatment biopsies help in arriving at the correct diagnosis and prevent unnecessary additional investigations. Grading of fibrosis, size of the residual tumor and presence of necrosis should be mentioned in the final pathology report of the post chemotherapy specimens as they have prognostic significance.
