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Introduction: Chronic suppurative otitis media (CSOM) can cause intracranial and extracranial complications. Reducing its prevalence may have both immediate and long-term health advantages. Understanding the local microbial flora in CSOM is critical before beginning empirical therapy. Our study sought to evaluate the link between bacterial profiles and demographic features in patients admitted to tertiary care institutions with persistent suppurative otitis media infections. Materials & Methods: The study was conducted in the Department of Microbiology at the Vijayanagar Institute of Medical Sciences in Ballari. Random selection was used to choose 109 CSOM cases who were admitted to ENT wards and visited outpatient departments. A proforma was used to record each patient’s age, sex, address, complete clinical information, and risk factors. Utilizing conventional microbiological techniques, bacterial isolates were obtained. Result: The largest percentages of patients (28.4%) were in the 1to 11years age range. Compared to women (36%), men were more impacted (64%). The prevalence of CSOM patients was higher in rural areas (66%) than in urban areas (34%). 86 of the 129 ear samples that tested positive for culture contained 100 bacterial isolates; Staphylococcus aureus 36 (36%) was the most frequently isolated pathogen, followed by Pseudomonas spp. Conclusion, CSOM affects both adults and children. CSOM is commonly dismissed as a minor public health concern. The incidence and morbidity of this disorder can be reduced with the support of health awareness initiatives, improved health education, and easy access to medical facilities.