Radiolucencies involving jaws, anatomic or pathologic are very common, which can occur both in maxilla and mandible. Among these, pathologic radiolucencies involving the midline of the mandible are rare. Despite advanced diagnostic methods, radiograph still remains the first and the most important investigation method. Even an extensive literature search did not yield a proper classification system for radiolucencies crossing the midline of mandible. To help the practitioner narrow down the differential diagnosis, a review of English literature was done and 134 articles found appropriate were selected. Apart from Central Giant Cell Granuloma, which was the most common radiolucency crossing the midline of mandible, 27 other lesions were detected, making the total number to 28. Based on this review, a classification system for radiolucencies crossing the midline of the mandible has been proposed.
