Introduction: Amitraz is a member of the formamidine pesticide indicated for the treatment of generalized demodicosis in dogs, for control of ticks and mites on cattle and sheep. Amitraz has a2- agonist stimulatory actions responsible for neurotoxic and preconvulsant effects. AIM: to study the clinical features, laboratory abnormalities, complications, and outcome of the patients with acute amitraz intoxication. Material and Methods: Our study is a prospective observational study done on 12 cases presented in emergency deptt. and got admitted in medicine deptt. of GMC Haldwani. Results: Analysis of the clinical features revealed mainly CNS involvement, miosis/mydriasis, hyperglycemia, polyuria, hypotension, bradycardia and nonspecific complaints like pain abdomen, vomitingetc. Treatment with a2-recepter antagonist Yohimibine was given to every case of amitraz poisoning and has shown improved survival even in critical cases in our study. Conclusion: In patients who presented with combination of exposure to an insecticide with features of hyperglycemia, drowsiness and features similar toorganophosphorous poison physician should always think of amitraz poisoning that will help to initiate rapid treatment for this rare, potentially life threatening intoxication
