The paper presents evidence-based results of clinical trials on the patients using nanosized particles in homeopathic tinctures of Aegle marmelos (A.M.) and Holarrhena antidysenterica (H.A.). As compared to the commercially available tinctures of A.M. or H.A., the combination of these two drugs prepared in the laboratory showed fast recovery of the patients with doses in liquid form varying according to the age and severity of the diseases. The results were confirmed using bacterial cultures. The in-vitro experiments of these tinctures with Gram positive and gram negative bacterial cultures show considerable improvement over the commercial tincture due to the reduced particle sizes. No toxicity was observed using these drugs in clinical trials. These tinctures thus have better drug resistance against bacteria. A.M fruit extract was used for green synthesis of silver nanoparticles (AgNPs). Plant Metabolites present in fruit extracts of A.M. were used to reduce Ag+ ions to AgNPs in a single-step green eco-friendly synthesis process. FTIR, UV and TEM analysis confirms the above reduction process.
