Background and Objective: Osteoarthritis knee is one of the major causes of disability among aged and relatively obese patients. The prevalence of Osteoarthritis is estimated as it is affecting 250 million people worldwide. To provide effective and safe mean of pain management associated with OA knee certain Unani regimens and formulations have been tested to validate their claims. Methods: This study was a open label, randomized, active control clinical trial on 35 patients, 20 patients in test group ( Habb with Zimad) and 15 patients in active control group (Hijama bila shart). Both groups were treated continuously for 15 days. The pre and post treatment effects of the study were assessed with Lequesne Index. Results: Lequesne Index (ISK) subscales of Pain and discomfort, ADL and Total scores are highly significant with p value < 0.001, Whereas, Maximum distance walk subscale is clinically significant but statistically insignificant. The results were analyzed statistically by using Paired‘t’ test, Friedman test and Kruskal Wallis test with Dunn’s multiple compare test. Interpretation and Conclusion: The findings of the study reveals that the interventions of both groups are effective in alleviate the symptoms of osteoarthritis knee. Test drug was found comparatively more effective than control.
