Ten clinically affected dogs of either sex and different age groups were divided into two groups consisting of five in each. Intramuscular injection of romifidine @ 30 µg/kg body weight and ketamine @ 5 mg/kg body weight was injected to group I and romifidine @ 40 µg/kg body weight along with ketamine @ 5 mg/kg body weight to group II. The induction time of 8.40 ± 0.24 minutes and 5.80 ± 0.37 minutes; duration of anaesthesia of 64.40 ± 0.81 minutes and 76.20 ± 0.96 minutes and recovery time of 86.40 ± 0.74 and 94.40 ± 0.67 minutes were recorded in group I and II respectively. Complete analgesia was present in group II. All the animals exhibited muscle relaxation, cessation of tail movement and salivation. Smooth induction and recovery were recorded in both the groups. In both groups heart rate, respiration rate, rectal temperature, tidal volume, minute volume and oxygen saturation decreased significantly (p < 0.05). Mean arterial pressure increased significantly (p < 0.05) in both the groups. Based on the observation, romifidine @ 40 µg/kg body weight and ketamine @ 5 mg/kg body weight could be recommended for surgical procedures. Romifidine @ 30 µg/kg body weight and ketamine @ 5mg/kg body weight is suggestive for minor surgical procedure.
