The objective of the study was to identify the determinants for regional variations of the ISR for districts of Tamil Nadu at local level and for Indian states at the global level. This exercise was also to compare for the period 2001 and 2011.Census of India data and published health reports on various determinants of ISR were used. Ordinary least square regression analysis was applied to understand which among the determinants are related to the ISR. Among the determinants of Tamil Nadu, the wasted pregnancy and infant mortality rate for the year 2001; and the percent persons below poverty line for 2011 were statistically significant. For India, the coefficient of the percentage of persons below poverty line (BPL) and infant mortality rate for the year 2001; female literacy, wasted pregnancy and percent of persons below poverty line for the year 2011 were statistically significant.
