Introduction: Removal of infected pulp tissue from the coronal portion leads to preservation of a remaining vital and functioning pulp. Preservation of pulp vitality by pulpotomy is one of the universally accepted treatment procedure with the aid of latest bioactive materials leading to a more conservative approach in the management of teeth involving the pulp based on clinical conditions. Aim: To comparatively evaluate the clinical and radiological outcome of single visit pulpotomy procedure using Biodentine and the combination of Plasma Rich Fibrin (PRF) and Biodentine Materials and Methods: Twenty permanent molars were selected and randomly assigned to two groups that included pulpotomy with only Biodentine and the other group with the PRF-Biodentine combination. Single visit pulpotomy procedure was completed with the restoration. Later the patients were recalled after one day, three months and six months for clinical and radiographical evaluation. Results: Chi-square test was used to compare the responses for various study variables between Biodentine and PRF-Biodentine combination. The comparison between the two groups was statistically not significant. Conclusion: Single visit pulpotomy procedure performed with either Biodentine or Combined PRF and Biodentine was equally efficient at 6 months follow-up. But with PRF-Biodentine combination, PRF an ideal biomaterial which is autologous can help better than Biodentine alone in the success of vital pulp therapy
