The aim of the present study was to compare the anti microbial activity of aqueous and methanolic extracts of various parts of the plants like pulp, leaf, seed, fruit peel and bark of Citrus maxima and Citrus aurantium on Escherichia coli, Staphylococcus aureus and Klebsiella pneumoniae. The methanolic extracts of the leaf, seed, fruit peel and bark of Citrus maxima exhibited anti bacterial activity against Escherichia coli and Klebsiella pneumoniae but no zone of inhibition was noticed with Staphylococcus aureus. The methanolic and aqueous extracts of the Citrus maxima pulp showed considerable antibacterial activity against all three bacteria. Therefore parts of these citrus plants contain compounds with medicinal and pharmacological importance.