A comparison of anesthetic efficacy of nalbuphine and dexmedetomidine as adjuvants to 0.5% ropivacaine and 2% lignocaine for supraclavicular brachial plexus block in upper limb surgeries

Research Article
*G. R. Santhilatha, M.D., G. G. N. Sudharani, M.D., B. Snehalatha, M.D., S. Rambabu, M.D., A. Venkateswara Rao, M.D., M. Aparna, M.D.
DOI: 
DOI: http://dx.doi.org/10.24327/ijrsr.20231412.0830
Subject: 
Medical
KeyWords: 
Nalbuphine, Dexmedetomidine, 0.5% Ropivacaine , 2% Lignocaine,Supraclavicular Brachial Plexus Block,Upper Limb Surgeries.
Abstract: 

Background: Anaesthetic Efficacy ofNalbuphine And Dexmedetomidine as an Adjuvant to 0.5% Ropivacaine & 2% Lignocaine for Supraclavicular Brachial Plexus Block  Aim: A Comparison of Anaesthetic Efficacy of Nalbuphine And Dexmedetomidine as an Adjuvant to 0.5% Ropivacaine &2% Lignocaine for Supraclavicular Brachial Plexus Block in Upper Limb Surgeries. Methods: After obtaining  ethics committee approval and written, informed valid consent, 100 patients were enrolled in the study. The  patients of either sex, ASA grade 1 and 2,Age 18- 60 years. All the patients posted for elective upper extremity surgeries below the shoulder joint and received block of Brachial plexus by a Supraclavicular technique. Group D:50 mcg of Dexmedetomidine (0.5ml of Dexmedetomidine and diluted with 0.5 ml sterile water) and 20ml of [100mg] 0.5% Ropivacaine with [200mg]10 ml of Lignocaine Group N:Nalbuphine (1 ml)-10 mg with 20 ml [100mg]0.5% Ropivacaine, [200mg]10 ml of Lignocaine. Results: Randomised controlled study was done by comparing Dexmedetomidine &Nalbuphine effects on the Brachial plexus block along with 0.5% Ropivacaine & 2% Lidocaine.

  • A group of 100 patients were divided into 2 groups of 50 each, group D & group N.
  • Group D received 50 mcg Dexmedetomidine along with 20 ml 0.5% Ropivacaine & 10 ml 2% Lidocaine.
  • Group N received 10 mg Nalbuphine along with 20 ml 0.5% Ropivacaine & 2% Lignocaine.
  • For Brachial plexus block,classical landmark based approach is followed.
  • Onset time of Sensory block, Motor block, duration of Sensory & Motor block, level of sedation &Hemodynamic parameters observed.
  • With the observational parameters,’t’ test applied and the sensory blockade onset time, faster onset of Motor blockade  seen in D group were statistically significant.
  • Duration of Sensory block, Motor blockalso prolonged in D group  was statistically significant.
  • Time for rescue analgesia prolonged in D group  is statistically significant.

Conclusion: By the observations from the study,by adding Dexmedetomidine 50 mcg compared to Nalbuphine 10mg with 0.5% Ropivacaine & 2% Lidocaine in Supraclavicular Brachial plexus block resulted in

  • Faster onset of Sensory block.
  • Faster onset of Motor block.
  • Prolonged duration of Sensory block.
  • Prolonged duration of Motor block.
  • Better Sedation intraoperatively.
  • No significant hemodynamic effects & adverse effects
  • Though Nalbuphine also was a good adjuvant,it had added benefit of low cost making it more economical for use.