Background: Dentine hypersensitivity is a common complaint among dental patients. Recently, a novel stabilized calcium sucrose phosphate dentifrice was introduced that offers a desensitizing benefit. The primary aim of this study was to compare the in vivo efficacy of this novel dentifrice with Calcium sodium phosphosilicate and a non-desensitizing dentifrice, on dentin hypersensitivity in a four-week period. Methods: Sixty volunteers with tooth sensitivity were recruited, and a double-blind, randomized, parallel, controlled clinical trial was conducted in a hospital setting. Clinical evaluation for dentin hypersensitivity by 0-10 VAS score was done using air blast, and cold water methods. Following baseline measures, subjects were randomly divided into three groups and treated as follows: Group A--dentifrice containing calcium sodium phosphosilicate (Novamin); Group B--dentifrice containing Calcium sucrose phosphate; and Group C—dentifrice containing no desensitizing ingredients. Clinical evaluations were repeated after two and four weeks of product use. Statistical analysis used: Mean VAS scores were compared among groups at different time points (baseline, and 2 and 4 weeks) and among groups at each time point using one-way analysis of variance. Results: Compared to baseline, there was a clinically significant decrease in dentin hypersensitivity in Groups A and B following four weeks use of the dentifrices containing calcium sodium phosphosilicate and calcium sucrose phosphate, respectively. The Group A dentrifice, however, was found to be significantly better in reducing the VAS score compared to the Group B and Group C dentrifices at any time point for both measures of sensitivity. Conclusion: The results suggest that the dentifrice containing 5% NovaMin provides rapid and significantly more relief from dentin hypersensitivity in four weeks compared to a dentifrice containing calcium sucrose phosphate or a non-desensitizing dentifrice
