computational study on the effect of patterned electrical stimulation in retinal ganglion cells

Research Article
Padma priya.K, Krishnan.J, Malathi.R
DOI: 
xxx-xxxx-xxx
Subject: 
Engineering
KeyWords: 
Action potential, Biphasic stimulation current, FCM model, Inter phase gap, Retina, Retinal Ganglion cell, synapses.
Abstract: 

Vision is the complex information processing which depends on the neural processing of the retina. The retina is a layer of tissue sensible to light. Light incident on the retina produces a series of electrical and chemical synapses which creates the nerve impulses. The retina has multi layered neurons interconnected by the synapses. The light passing the pupil gets focused by the lens presents an inverted image to the photoreceptors called the rods and cones. Neural signals from the rods and cones are processed in the retinal ganglion cells (RGC) whose axons form the optic nerve. These nervous messages are mostly associated with an electrical change known as the action potential. An all active Fohlmeister – Coleman – Miller (FCM) model is a computational model with five nonlinear ion channels is modeled for the electric field stimulation of the RGC, with an intracellular resistance (Ra) and a membrane mechanism in parallel with a membrane capacitance and also a gap junction conductance in between the compartments. The simulations were done for the above mentioned FCM neuron model and are analyzed by stimulating with a constant dc current and also with a patterned biphase current stimulation with Inter Phase Gap (IPG). The action potential of the designed RGC and the electrotonic current flowing across the boundaries were figured out for different values of stimulating current and gap junction conductances.