Conceptual Evolution In The Pathogenesis Of Periodontal Disease: Past, Present And Future

Chronic periodontitis is a multifactorial disease. Advanced mechanisms regarding the pathogenesis of periodontal disease have been developed due to the introduction of new technologies and expanding knowledge in the field of microbiology and genetics. The older models developed in the progression of periodontal disease could not identify innate and environmental differences amongst individuals that could alter the disease progression. Today, the emerging data about genomics, proteomics, and metabolomics can help us to develop new models which incorporate data about genes and proteins. New models in the next few years will just be a scaffold in order to integrate our knowledge available from the ‘‘-omics’’ technologies.