Ischemic heart disease (IHD) occurs due to imbalance between myocardial oxygen supply and demand. The aim of this study is to estimate, compare and correlate serum myeloperoxidase (MPO) and nitric oxide (NO) levels in newly diagnosed IHD subjects and healthy subjects. 30 acute IHD subjects and 30 age and sex matched controls were included in this study. Myeloperoxidase and nitric oxide were estimated. SPSS 16 was used to analyze the statistical data. High serum myeloperoxidase levels and low serum nitric oxide levels were observed in acute IHD subjects in comparison to controls. There was a negative and moderately significant correlation between serum MPO and NO in acute IHD subjects. Determination of serum MPO and NO in IHD may be useful in taking proper measures to prevent IHD.
