Ulcerative colitis (UC) is a chronic and recurrent inflammatory process that requires continuous treatment, so can affect the biochemical and hematological parameters. In this study, we aimed to investigate the correlation between UC activity and magnesium (Mg), mean platelet volume (MPV) and platelet distribution width (PDW). This study was conducted in a Gastroenterology Clinic. The patients' records between 2010 and 2017 were reviewed. The diagnosis of UC was made according to the guidelines for European Crohn's and Colitis Organization. The severity of Truelove and Witts was used to determine the severity of UC activity. MPV, PDW, and Mg values were compared according to the severity of UC activity of the patients with UC. The study included 77 inflammatory bowel disease male patients. Patients with mild UC activity had a higher MPV (9.5 ± 0.44), while the patients with severe UC activity had a lower MPV (7.1 ± 1.52) (p<0.001). Likewise, the patients with mild UC activity had the highest mean PDW (17.9 ± 1.04), while the patients with severe UC activity had the lowest mean PDW (14.8 ± 2.04) (p<0.001). As the severity of UC activity increased, the mean Mg value decreased. The Mg levels of the patients with mild UC activity (1.9 ± 0.14) were higher compared to that of other groups, while the Mg levels of the patients with severe UC activity (1.6 ± 0.09) were lower (p<0.001). Mg has an anti-inflammatory effect in inflammatory diseases and that Mg levels decrease as the disease activity increases, moreover the negative correlation between UC activity and MPV, PDW is demonstrated.
