Тhe commercialization and the rapid expansion of the Internet brought about the introduction of E- Commerce. E-Commerce can be designated as the greatest innovation of the 21st century, along with many benefits that emerged from its rapid development such as: expansion of the global market, increased significance of international management, approaching customers worldwide via computer networks and affiliating economies between countries. The Republic of Macedonia takes part in this global process and follows the trend of implementing E-Commerce, which opens new doors to business partners, markets and customers. This paper researches the implementation of E-Commerce in the Republic of Macedonia, and the attitude of Macedonian citizens towards electronic purchase and payment through the Internet. For the purpose of this paper, data were obtained from questionnaires, including 30 participants, from 25 to 35 years old, selected on the basis of subjective criteria, appropriate for the purpose of this study.