Type1diabetes (T1D) is the most common endocrine disease encountered in the pediatric age group.T1D results from a complex interplay of genetic, immunological and environmental factors. Although the disease is characterized by β cell destruction and presence of pancreatic auto antibodies, the autoimmune attack may involve other organs particularly thyroid, gut, adrenals and gastric parietal cells. The presence of autoimmunity of other organs in patients with T1D influences the disease prognosis and screening for associated autoimmunity is therefore recommended. There is however wide variation in the frequencies of various auto antibodies in different populations of the world and the frequency of screening and the follow up of patients with positive auto antibodies remain controversial. Only a few studies have evaluated more than 3 auto antibodies at a time. Therefore more research is needed to evaluate pancreatic, thyroid, celiac autoantibody positivity in Indian children with DM.
