Introduction: Urinary tract infection (UTI) constitute the first reason for consultation and medical prescription and the leading cause of infection in community medicine justifying antibiotic treatment. To our best knowledge this first Moroccan study which aims to evaluate the frequency of isolation and antimicrobial susceptibility of uropathogenic Escherichia coli strains isolated from non-hospital settings in Morocco. Patients and Methods: This a multicentre prospective study conducted in 20 medical analysis laboratories in eight major cities in Morocco (Rabat, Sale, Kenitra, Marrakech, Meknes, Settat, ElJadida, Tanger). Results: In this study, 3,400 uropathogenic enterobacteriaceae were isolated, including 2555 nonrepetitive strains of E. coli, an overall isolation rate of 67%.Women represent 73% of infected patients, confirming the frequency of urinary infections in women. The susceptibility rate of E.coli toamoxicillin, amoxicillin-clavulanic acid, céfixime, cefotaxime, ceftriaxone, ceftazidime, ertapenem, imipenem, nalidixic acid, ofloxacin, norfloxacin, ciprofloxacin, gentamicin, cotrimoxazole, nitrofurans and fosfomycine was 35.3%, 56%, 82.4%, 85%, 78.7%, 85.5%, 84.5%, 99%, 69.7%, 66.5%, 65.3%, 70%, 86%, 54%, 91.1% and 97% respectively. E. coli producing extended spectrum β-lactamase constituted 2.3% of all uropathogens E .coli. Conclusion: The emergence and dissemination of multiresistanturopathogens Escherichia coli are a real public health problem and a real challenge for biologists, clinicians, hygienists and health authorities. The adoption of policy for the proper use of antibiotics, updated through regular monitoring programs of the susceptibility of bacteria to antibiotics, remains one of the key tools for reducing the magnitude of the phenomenon of bacterial resistance to antibiotics.
