Cycloaddition Reaction Using Baylis-Hillman Adducts

A simple method for the synthesis of triazole derivatives having a methoxy carbonyl or acetyl group at C-5 via an intramolecular 1,3 dipolar cycloaddition reaction of azide enynes have also been reported in the literature. Due to the interesting and important biological properties of these tricyclic pyrrolidines, developed the 1,3-dipolar cycloaddition of linear azido alkynes derived from protected β-amino esters proceeds via diastereomeric differentiation to provide trans-disubstituted triazolodiazepines with various substituents represents an attractive and interesting endeavor in synthetic organic chemistry and medicinal chemistry.