Introduction: Children with Tetralogy of Fallot (TOF), a cyanotic type of congenital heart disease can present with significant oral health risk. The present article discusses the dental management of one such case under general anesthesia. Aims and objectives: The aim of this case report is to furnish the fundamentals of managing a child with TOF on a dental and anesthetic prospective. The objectives include proper examination, prophylactic/therapeutic measures and special considerations along with a proper interdisciplinary approach. Materials and methods: A brief case history was obtained followed by a thorough clinical examination after which preventive and corrective dental treatment protocols were planned. Considering the patient's general and oral health, full mouth rehabilitation was done under general anesthesia in a single visit. Various precautionary measures were taken considering her cardiac condition during general anesthesia administration. Results: The entire dental needs were met with safe anesthesia, minimal stress and discomfort to the child. The comprehensive treatment plan helped to restore good oral health. Conclusion: This case report highlights the precautionary measures to be followed during the administration of general anesthesia to prevent the risks and potential complications associated with it in patients with congenital heart disease. It also emphasizes the essentials of planning a structured and multi-disciplinary treatment plan for a child with TOF.