Eclampsia and preeclampsia is an acute and life threatening complication during pregnancy. Hydralazine hydrochloride is one of the drugs of choice in treating this condition. The purpose of the present research work was to formulate the orodispersible tablets by using different methods and provide a suitable patient convenience dosage form to enhance the bioavailability and provide quick onset of action. Formulation of orodispersible tablets of Hydralazine hydrochloride were prepared by using various superdisintegrants like crosspovidone, crosscarmellose sodium and sodium starch glycolate by direct compression method and camphor as an excipient by sublimation technique. The formulas were evaluated for compatibility and Precompressional studies. The formulations were evaluated for weight variation, thickness, hardness, friability, content uniformity, disintegration time, wetting time, water absorption ratio and release profile. Among all the formulations F9 and SF9 showed effective percentage of drug release at 12 minutes indicating faster and maximum absorption at the site of administration.
