Sydnones are very important members of the class mesoionic compounds. A series of schiff base derivatives has been synthesized by condensing 4-(((4-aminophenyl) amino) methyl)-3-(3-nitrophenyl)sydnone with KCNS and Br2 in presence of glacial HAc- followed by the reaction with substituted aromatic aldehydes. The synthesized compounds were characterised and evaluated for antimicrobial activities. The newly synthesized compounds were screened against representatives of Gram-positive and Gram-negative bacteria and fungi. Compounds 7b and 7i found active against Gram-positive and compounds 7f and 7j found active against Gram-negative bacterial strain and compound 7h found active against fungal strain. All the synthesized compounds were characterized by elemental analysis, FT-IR,
1H-NMR spectra and13 C-NMR.
