This study aimed to investigate the relationship between early maladaptive schemas and coping ways of multiple sclerosis patients. Research method was descriptive correlation. Statistical community in this study included all M.S patients of Mazandaran Province (N=1710). Sample size was decided to be 313 persons selected through random sampling and based on Morgan’s table. Research data were collected using Young’s early maladaptive schemes questionnaire (short form) and Lazarus and Folkman’s coping strategies questionnaire. Data collected were analyzed by Spearman’s correlation coefficient and stepwise regression. Analysis of data showed that there is a negative correlation between early maladaptive schemas and problem-oriented coping and a positive correlation between early maladaptive schemas and emotional-oriented coping. It can be concluded that early maladaptive schemas play a determinative role in coping styles of M.S patients.