Environmental pollutants and Heavy metals (Hg, Al, Se, etc.) have ability to alter the function of endocrine gland in humans which leads to interrupt the synthesis and secretion of hormones in the body. Itis speculated that prolonged occupational and environmental exposure of toxicants is responsible forsuppression of thyroid hormones. The aim of present study is to determine serum Thyroid StimulatingHormone level and biochemical parameters in Coal mine workers as well in residing population ofChandrapur district, Maharashtra. Total n=94 serum samples were collected from coal mine workers(n=46) and non exposed (n=48) subjects. Statistical data processing was done by using SPSS and Medcalcsoftware. Statistically significant increased of serum TSH (p< 0.0001) was noted in coal miners 3.68 ±0.99 as compared to non exposed 1.99 ± 0.57 subjects. Slightly positive Pearson’s correlation wasobserved in serum TSH with Creatinine (r=0.196) and urea(r=0.35) but statistically insignificant. On thebasis of finding, serum TSH and Creatinine may be used as potential marker for preliminary toxicitydetermination among coal mine workers.
