Gastroretentive drug delivery system is one of the important approaches to achieve gastric retention to obtain sufficient drug bioavailability. This delivery systems is desirable for drugs with an absorption window in the stomach or in the upper small intestine. This have a bulk density less than gastric fluid & the drug is released slowly as a desired rate from the system. After release of drug, the residual system is emptied from the stomach. This result in an increased gastric retention time (GRT) & a better control of the fluctuation in plasma drug concentration. Here, we use glipizide as the candidate drug which a second generation sulfonyl urea used as an anti-diabetic drug. It undergoes enterohepatic circulation. It acts on sulfonyl urea receptor. It produces action by blocking potassium channel in β-cell of islet of langerhans by which calcium channel get activated & increase more insulin release from individual β-cell. Gellan gum, magnesium stearate are used for the formulation of this glipizide microbeads. Here, we detect the sizes, densities, percentages of swelling of glipizide beads & percentages of drug entrapment efficiency to show that it may affect release time of active ingredient in tablet but not reduce the overall bioavailability of candidate drug.
