Weed management through chemical herbicides creates spray drift hazards and adversely affects the environment. Besides, herbicide residues in food commodities, directly or indirectly, affect human health. These effects lead to the search for an alternate method of weed management which is ecofriendly. In this regard, biological approaches are gaining momentum. They include a high degree of specificity to target weed, with no effect on non-target and beneficial plants or man, absence of weed resistance development, and absence of residue build-up in the environment. Currently, fungal weed control is rapidly developing natural phenomena in research areas with implications for plant yield and food production. Fungal weed control may help to maintain the quality of crops and reduce the use of chemical pesticides and other toxic chemicals and offer important natural mortality factors for weed population control under natural environmental conditions. The application of the fungal spores, fermented broth, and their crude metabolite or purified metabolites is a very good source for natural herbicide for the management of Parthenium weed. Fungal weed pathogens can produce a wide array of toxins, bioactive metabolites with different biological activities, chemical structures, mechanisms of action, specificity with respect to plants, and environmental impact and stability. This paper will discuss the current research progress on fungi and their secondary metabolite application for the management of Parthenium weed.
