In a common case of atherosclerosis and diabetes promote vascular endothelial disease, disorder of brain and heart function among human population, loss of cellular regulation which is tightly involved to circulation of electron and proton in 14 billion cell complex, named “The membraneredox potentials three-state line system dependent-full 9 stepped cycle of proton conductance” and deficiency of oxygen for energy and metabolism are a main causes for cell mediated every disorders in human body. Therefore, this research study is aimed to introduce new medicine named Antischemin for prevention of cellular disorder in metabolism and improvement of blood circulation and regulation of blood coagulation at the pathogenic models. Conclusion: In acute, subacute and chronic phase of diabetic model, comparing to INR, PT had no difference but INR had increased by 8.8-14.4%, aPTT increased by 10.26-40.9%, TT increased by 17.3-29.7% and fibrinogen increased by 30-60.5%. This indicates thrombocyte activation and aggregation in blood circulation is more significant on days 3-14. Comparing Antischemin group with 100 mg/kg and control group, there was no difference in PT but INR, aPTT and TT increased by 16.6-18.8%, 10-24.8% and 12.35-33.25% respectively. Fibrinogen decreased by 40.5% indicating that it inhibits thrombocyte aggregation, coagulation and increased blood rheologic properties in blood.
