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The common carp, Cyprinus carpio was exposed to 1/10th of 96 hours LC50 concentrations (0.02ppm) of glyphosate for 10, 20 and 30 days. The biochemical parameters like protein, carbohydrate and lipid were measured in gill, liver, kidney and muscle both in control and experimental fishes. During various exposure periods the levels of protein, carbohydrate and lipid decreased significantly over the control. The muscle tissue showed maximum decline in protein, carbohydrate, where as the liver showed maximum decline in lipid content during the exposure periods. Monitoring of blood parameters, both cellular and non cellular may have considerable diagnostic value in assessing early warning signs of herbicide poisoning. Due to glyphosate exposure the blood parameters such as RBC, Hb, MCV, MCH, MCHC and PCV decreased whereas WBC increased with respect to control.