Medicinal plants are inexhaustible sources of bioactive compounds with varied pharmacological properties. Among them, the Morinda citrifolia L. (Rubiaceae), popularly known as Noni, looked to the scientific community because of their anti-inflammatory and immunomodulatory effects. The rational use of drugs and herbal medicines, it is considered major pharmacological properties of validation by means of preliminary studies in vitro and in vivo. The study evaluated formulated nanostructured base hydroalcoholic extract Morinda citrifolia L. (Noni) conveyed in enteral form, in an experimental model of septic cecal ligation and puncture (CLP). The study consisted of 2 groups of 6 animals, where the controls were treated with 0.9% saline solution (C) and the abdominal sepsis group (CLP) treated with 5 mg/mL/Kg Noni nanoemulsion (SME-FC5). Orally by gavage 12h and 2h before the experiment. Treatment response was assessed by blood count, inflammatory markers and biochemical dosages, including hepatic histopathological analysis. There was a reduction of inflammatory markers, maintenance of normal hematological parameters in addition to the preservation of laboratory functions, and histologically. It was concluded therefore that the structured nano extract Morinda citrifolia L (Noni) positively influenced the organic reactions in the presence of sepsis, reducing the production of proinflammatory cytokines, preventing tissue injury and attenuating the systemic inflammatory response against the experimental model of polymicrobial sepsis.
