Objective: To investigate the protective effect of sesamol in rotenone-induced rat model of Parkinson’s disease by biochemical and histopathological studies. Male Wistar albino rats were subjected to study for 60 days (n=6: I- vehicle control, II- rotenone (3 mg/kg.B.wt intraperitoneal), III- rotenone + sesamol (50 mg/kg.B.wt intraperitoneal), IV- rotenone + sesamol + L-DOPA (10 mg/kg.B.wt oral), V- rotenone + L-DOPA).The organs (brain, liver, kidney, heart and spleen) of experimental rats were weighed. Biochemical parameters like urea, uric acid, creatinine, blood urea nitrogen, aspartate transaminase, alanine transaminase, alkaline phosphatase, lactate dehydrogenase, total protein, albumin and globulin were determined. The histopathology of liver, kidney, heart, spleen and intestine were performed. Sesamol administration has attenuated the alterations caused by rotenone. These results suggest that sesamol can be a potential therapeutic for the treatment of Parkinson’s disease by serving as a neuroprotective compound.
