Diabetes mellitus is characterized by the disturbances of carbohydrate, protein and lipid metabolism, with a high risk of morbidity and mortality from primary as well as secondary complications. However various drugs are found for the treatment of diabetes, none is found to be ideal due to the unwanted side effects associated with long term treatment. The present study was aimed to investigate the effect of tannic acids on lipid peroxidation and antioxidants in plasma and liver in streptozotocin induced diabetic rats. Diabetic mellitius was induced by single introperitoneal injection of streptozotocin (40mg/kg b.w) in albino Wister rats. Oral administration of tannic acid (200mg/kg b.w) by gastric gavage to diabetic animals significantly reduced the level of lipid peroxidation and increased the level of antioxidant enzymes. The results of this study clearly show the tannic acid possesses antioxidant and anti lipid peroxidation properties.
