Nursing profession is focused on providing care to individual, family, or community so they may attain, maintain, or recover optimal health. Nurses are different from other health care providers as the approach of nursing mainly focuses on patient care, training and health promotion. Nursing education faces challenges pertaining to provision of these clinical skills. Simulation training is one of the key which helps to develop the skill and clinical reasoning. Modern nursing education system has adopted simulation based learning through which students can be exposed to various clinical skills. It also helps in building confidence among nursing students. Aim of the study is evaluate the effectiveness of skill based simulation training programme on insertion of indwelling urinary catheter. A quasi-experimental one group pre-test post-test research design was adopted for the study. The sample consisted of 57 first year BSc nursing students who were selected by simple random sampling technique. The results were computed by obtaining mean difference between pre test and post test skill scores which were 11.09±2.23 and 23.35±3.04 respectively. This showed significant increase in skill pertaining to indwelling catheterization. The study revealed that the simulation learning programme is an effective means in increasing the skill level of the student nurses on insertion of indwelling urinary catheter.