The aims of this study are evaluated the in-vitro antibacterial activity of the crude ethanolic (EOH) and methanolic (MOH) extracts of Calligonum comosum L'her. extracted by Maceration (MM) and Ultrasound (UM) methods on three strains bacteria’s: Two Gram negative (Escherichia coli ATCC 25922 and Pseudomonas aeruginosa ATCC 27853 ) and One Gram positive (Staphylococcus aureus ATCC 25923). The activity of different extracts of C. comosum reveals a high sensitivity of the tested germs except for E. coli especially with: EOH UM and MOH MM, also showed very expressive inhibition diameters (44 - 28 mm) with three antibiotics tested (AMC30, AK30, AM10), and showed medium resistance with different concentrations of the EOH MM and MOH UM.
P. aeruginosa is very sensitive to high concentrations of the antibiotic AK30 (37mm) and MOH UM (9.5 mm with concentration 0.5mg/ml and 14 mm with concentration 2mg/ml). As against this strain is resisted the two antibiotics AM10, AMC30 and the different concentration of MOH MM this is probably due to the possibility of the absent chemicals compounds in this extract.
The most important antibacterial effect is observed with S. aureus to all concentrations of Four extracts and Three antibiotics tested
