Cancer-related pain is one of the most prevalent and incapacitating cancer-related side effects across all cancers, and its prevalence is anticipated to increase along with the expected increase in cancer survivors in ensuing decades. Pain from any source that manifests at any stage of cancer continuum (from diagnosis to end of life) is referred to as cancer-related pain. Visceral, neuropathic, nociceptive and musculoskeletal pain are few types of cancer-related pain which can be caused by tumour and cancer treatment such as surgery, chemotherapy, or radiotherapy, or disorders that affect cancer survivors. Among cancer patients, observational data suggests that those who exercise more frequently experience less pain than those who exercise less frequently. To avoid such incidences, the concerned study has been taken up to assess the efficacy of isometric exercises on benefits of knee joint pain among cancer patients, from April to July 2023 which represents a decrease in level of knee pain scores among cancer patients where, the calculated p-value is 4.87 which is highly significant i.e., greater than the table value 2.05 at 0.05 level of significance at df=29 & this data signifies that isometric exercises are effective in imparting a decrease in the level of knee pain among patients receiving Chemotherapy & radiotherapy.