Ethnomedicine derived from medicinal plants are used by above 60 percent of the global population. This article focus on Tiruchirappalli herbal drugs and plants used in the treatment of dengue. There are various approaches to reduce the ill effects of dengue and its secondary complications, herbal formulation are preferred due to lesser side effects and low cost. Botanical study was undertaken to collect the information from Tiruchirappalli District in Tamilnadu. The traditional knowledge of traditional healer and medicinal practices on medicinal plants was collect through questionaries’ and personal interviews during field trips. The study area field visits conducted during June to November 2017. 51 species of medicinal plants of dengue and malaria were reported the survey and having discussion with local traditional healers and local peoples. These medicinal plants belongs to 30 families. This studies show that the peoples still continue to depend on medicinal plants, however the traditional healer are on the decline because the younger generation of the people have no interest and knowledge of this form of medicine as they have started moving towards the towns and cities. Therefore, it is necessary to document the plants to effectively conserve these.