Psychoactive substance such as Alcohol, Heroine, Opioids, and Cannabis etc. has been used by human in all culture from prehistoric period. People abuse these substances for many different reasons. Continuous use of substance may alter brain function which lead many mental disorder. Aim of the study to evaluate the effectiveness of cognitive Behaviour Therapy (CBT) on depression among detoxified inmates. The research design was adopted for the study was quasi experimental non-equivalent control group design. Researcher planed face-to-face interview to collect the data. The tool consisted of demographic variables (Personal or Clinical data) & Beck Depression Inventory - II (BDI-II) was used. The study sample consist 131 detoxified inmates (experimental group = 70, control group = 61). In which 08 CBT sessions (weekly once) were provided by the researcher in a counselling room set-up. The finding of the study showed that in experimental group pre-test – follow-up mean difference was 15.55, ‘t’ value was 28.429, (P = 0.001,Significant), where as in control group pre-test – follow-up mean difference was 11.06, ‘t’ value was 18.526,(P = 0.001, significant). The result revealed that CBT was more effective on depression in experimental group as compare to control group.
