Cardiovascular disease is a major cause of mortality in patients with mild to moderate kidney disease and End Stage Renal Disease [ESRD]. Dyslipidemia is a well known risk factor for cardiovascular disease. Methodology: This is a case-control study done to compare the levels of blood lipids in patients of CKD with healthy controls. The patients were subjected to CBP, RBS, Blood Urea, S.Creatinine, CUE and USG ABDOMEN. Results: Shown that patients with CKD had significantly lower levels of HDL and higher levels of all other lipids when compared to controls. Conclusion: There is a negative correlation between serum HDL-Cholesterol and severity of renal failure and positive correlation between the ratio of Total Cholesterol to HDL-Cholesterol and severity of CKD.