Formulation of Gastroretentive floating mucoadhesive tablet which would remainin stomach for prolonged period of time thereby maximizing the drug release at the desired site for stipulated time. Repaglinide is having half life 60 min; to improve its half life by using excipient like HPMC k15M, HPMC k100M and Xanthan gum as polymer, Optimization using 32 fullfactorial design to study stability testing of optimized formulation. Method- The tablet formulation prepared by direct compression method. Prepared formulation were evaluated in terms of their physical properties, hardness, % friability, weight variation, content uniformity, in-vitro release, floating properties, mucoadhesive strength and swelling index. The classical zero order release curve was found to be linear (R2 ≥ 0.90). For the Korsemeyer’s Peppas release curves R2 was found to be ≥ 0.90for all 9 formulations. Result- FTIR and DSC studies showed no evidence of interactions between drug, polymers, and excipients. The best in-vitro drug release profile was achieved with the formulation F7 is 95.96 % after 12 h, which contain10 mg drug, 25 mg HPMC K15M, 50 mg HPMC K100M and 25 mg Xanthan gum. The floating lag time of formulation F7 was found to be 78±0.04sec. to98±0.05sec. The in-vitro release kinetics studies reveal that all formulations show Zero order and anomalous or nonfickiandiffusion. The stability study and no change in anyphysical characteristics and drug content over a 2 monthsperiod at 40±2°C. Conclusion-Study concluded that successful stable formulation of Gastro retentive floating mucoadhesive drug delivery system of Repaglinide can be prepared to maximize drug release at desired site for stipulated time.
