Constitutional delay in growth and puberty (CDGP) is a common clinical observation in childhood. Ghrelin may play a role in puberty initiation and progress. We aim to evaluate the association between ghrelin and CDGP. Case control study was conducted on 51 adolescent boys, 25 aged 14 – 18 years with CDGP (cases) and 26 healthy adolescent boys matched for age (control). Participants were subjected to history, clinical examination and investigations including CBC, ESR, Fasting blood glucose, TSH, Free T4, Growth hormone, Prolactin, FSH, LH, Testosterone, Ghrelin , Plain X-ray left wrist for bone age. Our study showed a highly significant difference between both groups in serum ghrelin (P=0.000), a highly significant negative correlation between ghrelin and FSH and serum testosterone (P < 0.001) and significant negative correlation between serum ghrelin and LH and growth hormone. (P < 0.05).Ghrelin level is associated with Constitutional delay in growth and puberty.
