An outbreak of Peste des petits ruminant (PPR) in an unorganised farm was recorded in Beltola area of Guwahati, Assam. Symptoms of high fever (106ºF), anorexia, lacrimation, severe diarrhoea, reluctant to move on account of abdominal pain and cramping were recorded in affected goats (n=15) with morbidity and mortality rates of 100 and 20 per cent, respectively. The animals recovered in 5 days post treatment with an overall recovery rate of 87 per cent. Antibodies against PPR virus were determined with the help of competitive enzyme linked immunosorbent assay technique (c-ELISA). PPR positive blood and serum samples (n=7) as well as control (n=7) were subjected to complete blood count and biochemical tests. Haematological parameters revealed a significant decrease (p<0.05) in the mean Hb and RBC values whereas significant increase (p<0.05) in the mean WBC and PCV values in PPR infected goats in comparison to that of control group. Biochemical parameters, showed significant (p<0.05) increase in the mean creatinine, total bilirubin and BUN values. Treatment initiated with a single dose of levamisole @ 2.5 mg/ kg body wt. subcutaneously and metronidazoles @ 10 mg / kg body wt. intravenously once daily for 5 days lead to uneventful recovery.
