Introduction: Diabetes mellitus (DM) is a group of metabolic diseases which if not controlled can cause life threatening complications. We hypothesize IGF-1 and Magnesium level can be used as a Biomarker for early diagnosing cardiovascular complications in the Type 2 Diabetic patients in the rural region of Vidarbha, Maharashtra, India. Methods and Materials: Fasting (FBS) and Post meal blood sugar (PMBG), total cholesterol (TC), high density lipoprotein (HDL), low density lipoprotein (LDL), very low density lipoprotein (VLDL), triglyceride (TG), Insulin Like Growth Factor-1 (IGF-1) and Magnesium (Mg) levels were evaluated. Total sample size was 80, which was divided into 40 study group with type 2 DM who attended the Medicine OPD of AVBRH Hospital and 40 age and sex matched healthy controls included in the study. Statistical Analysis: Software used in the analysis were SPSS 22.0 version and GraphPad Prism 6.0 version. Results: Serum lipid profile showed higher mean of TC, TG and LDL in patients with diabetes. IGF-1and Magnesium concentrations were significantly lower in subjects with diabetes as compared to the controls (p<0.0001). In multivariate regression analysis between IGF-1 and other parameters we have found only Magnesium correlates with IGF-1 level and it is statistically significant. Conclusions: Early detection of IGF-1, Magnesium and lipid profile abnormalities can minimize the risk for development of cardiovascular complications in the type II diabetic patients. IGF-1and Magnesium levels may be a useful marker for identifying subjects at risk for cardiovascular disease in the Type 2 diabetics.
