India being an agricultural country, the pesticide usage causes a serious environmental and public health problem. Due to large demand of food many farmers are resorting to extensive and rather over use of organophosphate pesticides to increase their agricultural yields. The sprayers who are involved in the spraying activity of pesticides in fields get the direct exposure of pesticides due to unsafe and non-preventive work practices. They do not use the safety masks, gloves and other protective gears during the spraying of pesticides which results into the access of pesticides in the blood stream through inhalation and dermal exposure which can adversely affect their eyes, skin and the respiratory system. In the present study changes in the neurotransmitter enzymes such as acetyl and butryl cholinesterase’s are studied in agricultural workers exposed to organophosphorous pesticides during agriculture practices of spraying in the areas of Nambur, Guntur district, A.P, INDIA. These changes are significant as it was found to be more than 45% in Acetyl cholinesterase (AChE). First absorption, by people resulting toxicity as chronic by the production of oxygen free radicals, being heterotrophic metabolically, results in the alteration of homeostasis leading to oxidative stress that culminates the non maintenance of the antioxidants continuously due to imbalance.
