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Hyperglycemic patients increase year by year throughout the world and 2nd leading cause of death after heart disease and cancer in many developed countries. Diabetes mellitus is a clinical condition characterized by increased blood glucose level (hyperglycemia) due to insufficient or inefficient insulin. An important feature of diabetes is that the body cells are starved of glucose despite its very high concentration around i.e., scarcity in plenty. Diabetes is a major cause of blindness, renal failure, amputation, heart attacks and stroke. Many plants have been used for the treatment of diabetes mellitus in Indian system of medicine and in other ancient systems of the world. Out of these only a few have been evaluated as per modern system of medicine. Plants have been used both in the prevention and cure of various diseases of humans and their pets. Since the plant products have less side effects, they have the potential as good hypoglycemic drugs. They may also provide clues for the development of new and better oral drugs for diabetes. With the advent of human civilization, many systems of therapy have been developed primarily based on plants.