The aim of the present study was to investigate the genotoxic effects of lead acetate in different somatic tissues (Intestine and RBCs) of skittering frog (Euphlyctis cyanophlyctis) using micronucleus test. LC50 value of lead acetate was calculated to be 42mg/kg. The four different sublethal concentrations of lead acetate (4.5, 9.0, 18.0 and 36.0mg/kg) were injected intraperitoneally once in the treatment period for 24, 48, 72 and 96hrs. It was observed that this heavy metal induced a significant increase in frequency of micronuclei at different concentrations in frog for 24, 46, 72 and 96hrs when compared with the control. These results lead us to the conclusion that lead may have genotoxic and cytotoxic properties due to the induction in the frequencies of MN in different tissues of the frog
