The incidence of Ventilator associated pneumonia (VAP) is on a rise in Intensive care units (ICU’s) leading to burden of costs due to increased length of stay, morbidity and mortality. The compliance to practices by nurses on Ventilator associated pneumonia prevention guidelines can lower the incidence of VAP in ICU’s. This article aims to assess the compliance to VAP prevention guidelines among intensive care nurses. A descriptive approach was used to assess the practices of 150 nurses working in ICU’s of multispecialty hospitals using non- probability convenient sampling. Data was collected using structured observational checklist on practices followed by nurses for prevention of VAP. Present study found nurses lacking incompliance to practices on VAP prevention. Regular in-service education programme in hospitals is required to keep the nurses updated with evidencebased guidelines to achieve positive patient outcomes.