Background: Doxorubicin induced cardiotoxicity includes various cardiac effects ranging from mild arrhythmias to cardiomyopathy. Coronary endothelial cells regarded as sites for the action of IL-17, via producing neutrophil chemoattractants and expressing adhesion molecules concerned in leukocyte migrations. Therefore, coronary endothelium regarded a principal consign of IL-17 role. Tacrolimus prevent mitochondrial permeability transition pore opening at the onset of reperfusion so it will limiting myocardial infarction size and cardiotoxicity.
Aim: The aim of present study is to evaluate the role of IL-17 in detection of cardiotoxicity and elucidate the cardioprotective effects of tacrolimus in doxorubicin-induced cardiotoxicity.
Methods and results: Sixty Dwale –Sprague male rats where used in this study to observe the cardioprotective effects of tacrlimus in doxorubicin induced cardiotoxicity. Doxorubicin produces significant elevation in serum MDA, LDH, Troponin and IL-17 levels as compared to the control group. While pre-treatment with tacrolimus there was a significant reduction (p<0.05) in serum MDA, LDH, Troponin and IL-17 levels as compared to the control group.
Conclusion: In conclusion tacrolimus produce significant cardioprotection from doxorubicin induced cardiotoxicity with lowering IL-17 serum level.
