IABP is used as a supportive treatment tool in a clinical context that will improve myocardial oxygen perfusion while at the same time increasing cardiac output. It actively deflates in systole & inflates in diastole, increasing blood flow to the coronary arteries. “A study was conducted to assess the effectiveness of structured teaching programme (STP) on knowledge regarding intra-aortic balloon pump (IABP) implantation therapy in coronary artery bypass grafting (CABG) among the staff nurses of selected hospitals in Dehradun.”A quasi-experimental one group pre and post-test design, consisted of 60 staff nurses selected by purposive sampling technique. Majority 71.7% staff nurses had reported adequate knowledge regarding IABP after structured teaching programme. The assessment of effectiveness of structured teaching programme on knowledge of staff nurses regarding IABP, revealed that, the knowledge increased after intervention is 48.96 percent at p<0.05 using Structured Knowledge Questionnaire. Hence it is inferred that, knowledge score of staff nurses after STP has increased significantly.