The aim of this study was to assess the effectiveness of structured teaching programme on knowledge regarding prevention and management of respiratory tract infection in children, among the mothers. A quasi experimental pre test post test design was adopted. 50 mothers having children aged 0 to 5 years were selected by using purposive sampling technique. The pre test data collected using demographic Performa and a structured knowledge questionnaire on prevention and management of respiratory tract infection in children, among the mothers of selected rural community area. After that structured teaching programme was administered and post test was conducted on the 8th day to the samples. The pre test knowledge score showed that 14% had adequate knowledge and 84% had average knowledge on prevention and management of respiratory tract infection in children. In the post test 6% were graded as average knowledge, 80% had adequate knowledge and 14% were graded as excellent knowledge after the7th day of administration of teaching programme.